- 23 July 2010- Hon’ble Prime Minister of the People’s Republic of Bangladesh Sheikh Hasina visited Shyamnagar area of Cyclone Aila devastated Satkhira district and promised to establish a medical college in Satkhira district. As a result of this, the foundation stone was laid on 20th July 2012. The construction work started thereafter.
- Academic activities of Satkhira Medical College started in a rented house in Satkhira town with 52 students in academic year 2011-12.
- Later in September 2013 administrative, academic and students’ accommodation was arranged in 6 buildings of Satkhira Medical College Hospital in Bakal, Satkhira.
- On 04 April 2015, the then Minister of Health and Family Welfare late Mr. Md. Nasim announced the auspicious opening of Satkhira Medical College Hospital.
- Since January 2018, Satkhira Medical College has been functioning in its own campus.